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Carbon monoxide (CO) emission constitutes the most widely used tracer of the bulk molecular gas in the interstellar medium (ISM) in extragalactic studies. The CO-to-H 2 conversion factor, α 12 CO(1−0) , links the observed CO emission to the total molecular gas mass. However, no single prescription perfectly describes the variation of α 12 CO(1−0) across all environments within and across galaxies as a function of metallicity, molecular gas opacity, line excitation, and other factors. Using spectral line observations of CO and its isotopologues mapped across a nearby galaxy, we can constrain the molecular gas conditions and link them to a variation in α 12 CO(1−0) . Here, we present new, wide-field (10 × 10 arcmin 2 ) IRAM 30-m telescope 1 mm and 3 mm line observations of 12 CO, 13 CO, and C 18 O across the nearby, grand-design, spiral galaxy M101. From the CO isotopologue line ratio analysis alone, we find that selective nucleosynthesis and changes in the opacity are the main drivers of the variation in the line emission across the galaxy. In a further analysis step, we estimated α 12 CO(1−0) using different approaches, including (i) via the dust mass surface density derived from far-IR emission as an independent tracer of the total gas surface density and (ii) local thermal equilibrium (LTE) based measurements using the optically thin 13 CO(1–0) intensity. We find an average value of ⟨ α 12 CO(1 − 0) ⟩ = 4.4  ±  0.9  M ⊙  pc −2  (K km s −1 ) −1 across the disk of the galaxy, with a decrease by a factor of 10 toward the 2 kpc central region. In contrast, we find LTE-based α 12 CO(1−0) values are lower by a factor of 2–3 across the disk relative to the dust-based result. Accounting for α 12 CO(1−0) variations, we found significantly reduced molecular gas depletion time by a factor 10 in the galaxy’s center. In conclusion, our result suggests implications for commonly derived scaling relations, such as an underestimation of the slope of the Kennicutt Schmidt law, if α 12 CO(1−0) variations are not accounted for. 

12CO and 13CO emission maps of the 30 Doradus molecular cloud in the Large Magellanic Cloud, obtained with the Atacama Large Millimeter/submillimeter Array (ALMA) during Cycle 7. See the associated article in the Astrophysical Journal, and README file, for details. Please cite the article if you use these data. 

Abstract The PHANGS program is building the first data set to enable the multiphase, multiscale study of star formation across the nearby spiral galaxy population. This effort is enabled by large survey programs with the Atacama Large Millimeter/submillimeter Array (ALMA), MUSE on the Very Large Telescope, and the Hubble Space Telescope (HST), with which we have obtained CO(2–1) imaging, optical spectroscopic mapping, and high-resolution UV–optical imaging, respectively. Here, we present PHANGS-HST, which has obtained NUV– U – B – V – I imaging of the disks of 38 spiral galaxies at distances of 4–23 Mpc, and parallel V - and I -band imaging of their halos, to provide a census of tens of thousands of compact star clusters and multiscale stellar associations. The combination of HST, ALMA, and VLT/MUSE observations will yield an unprecedented joint catalog of the observed and physical properties of ∼100,000 star clusters, associations, H ii regions, and molecular clouds. With these basic units of star formation, PHANGS will systematically chart the evolutionary cycling between gas and stars across a diversity of galactic environments found in nearby galaxies. We discuss the design of the PHANGS-HST survey and provide an overview of the HST data processing pipeline and first results. We highlight new methods for selecting star cluster candidates, morphological classification of candidates with convolutional neural networks, and identification of stellar associations over a range of physical scales with a watershed algorithm. We describe the cross-observatory imaging, catalogs, and software products to be released. The PHANGS high-level science products will seed a broad range of investigations, in particular, the study of embedded stellar populations and dust with the James Webb Space Telescope, for which a PHANGS Cycle 1 Treasury program to obtain eight-band 2–21 μ m imaging has been approved.